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breast cancer

U.S. FDA approves Pfizer’s high profile breast cancer drug

ID-10061252The FDA just approved Pfizer’s highly anticipated new drug for the treatment of breast cancer. Ibrance, also known as palbociclib, was approved for previously untreated postmenopausal women whose cancer cells have receptors to the female hormone estrogen and do not have mutations in the HER-2 gene that can contribute to uncontrolled growth of breast cells. This new mechanism of action blocks two enzymes involved in cell division, CDK4 and CDK6. This drug is intended to be used in combination with another cancer drug known as letrozole.The FDA granted the drug accelerated approval based on a 165-patient study showing that it slowed the progression of breast cancer. Experts estimate Ibrance could generate annual sales of $3 billion by 2020 and has the potential to become a new standard of care for advanced breast cancer. What are your thoughts?

For additional information click here

Photo courtesy of [scottchan]  freedigitalphotos.net

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Roche, Merck Extend Immunotherapy Fight to Breast Cancer

pink-breast-cancer-ribbon-10061252The upcoming San Antonio Breast Cancer Symposium on December 913 might bring two new potential treatments for breast cancer. Swiss drugmaker Roche and U.S. group Merck & Co are going to present data about their drugs to treat triple negative breast cancer (TNBC), which does not respond to either the hormonal therapy or to the drugs that target HER2 receptors. Roche’s investigational drug, MPDL3280A, has not been approved for any type of cancer yet while Merck’s product, Keytruda, has been approved for treating melanoma last month in the United States. Both medications are immunotherapy drugs that work by blocking a protein known as Programmed Death receptor (PD-1), or a related target PD-L1. Considering October is the breast cancer awareness month, what are your thoughts or concerns regarding these new therapies?

For more information, please visit Reuters.

Image courtesy of [scottchan] / FreeDigitalPhotos.net

Aloe plant gives hope to breast cancer treatment

Sliced Aloe Vera Stock PhotoKenyan researchers recently published a manuscript in the journal Molecules analyzing multiple chemical constituents from the roots of Aloe for their activity against breast cancer cells. Of those chemical constituents, two resulted in strong activity against specific breast cancer cells. This study may confirm Aloe’s traditional medicinal use of cytotoxicity and serve as a foundation for future medical innovations and research in breast cancer treatment. How do you think these findings will influence the oncology industry and future innovations for the treatment of breast cancer? What do you typically use Aloe roots and leaves for in your patients?
For additional information please see Molecules. http://www.mdpi.com/1420-3049/19/3/3264 — please use this link.

Image courtesy of [SOMMAI]freedigitalphotos.net

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

A Swedish study published in the journal Cancer Causes and Control suggested that the risk of breast cancer recurring in 600 patients taking tamoxifen was reduced with coffee consumption. Researchers evaluated hormone receptor status and also found modifications related to coffee consumption. What are your thoughts about this study – would the results encourage you to recommend coffee consumption to your breast cancer patients?

For additional information please refer to Cancer Causes and Control.

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

A Swedish study published in the journal Cancer Causes and Control suggested that the risk of breast cancer recurring in 600 patients taking tamoxifen was reduced with coffee consumption. Researchers evaluated hormone receptor status and also found modifications related to coffee consumption. What are your thoughts about this study – would the results encourage you to recommend coffee consumption to your breast cancer patients?For additional information please refer to Cancer Causes and Control.

Carotenoids may reduce the risk of breast cancer.

DSC_7628A study published in the Journal of the National Cancer Institute has shown that carotenoids may reduce the risk of breast cancer.  Carotenoids are micronutrients found in fruits and vegetables.  Data was pooled from 8 cohort studies that measured the level of carotenoids in the blood of over 3,000 women with breast cancer and nearly 4,000 women without breast cancer.  Women with the highest levels of carotenoids had a lower risk of breast cancer, especially estrogen receptor negative (ER-) breast cancer which usually has a poorer prognosis. What are your favorite dietary sources of carotenoids to recommend to the patients?

For more information, please read the abstract in the Journal of the National Cancer Institute.

“Image courtesy of [Suat Eman]/FreeDigitalPhotos.net

Decrease in breast cancer recurrence and death after 10 years of tamoxifen therapy

IMG_0220A new study published in the Lancet evaluated the effects of continued tamoxifen therapy on breast cancerrecurrence and survival. A total of 12,894 women with early breast cancer who had completed 5 years of treatment with tamoxifen were randomly allocated to continue tamoxifen to 10 years or stop at 5 years. The study found that women with ER-positive breast cancer who continued tamoxifen for 10 years had significant reductions in the risk of breast cancer recurrence, breast cancer mortality, and overall mortality especially after year 10.  How do you think this study will impact breast cancer treatment guidelines?

For more information about the study, pleasesee the abstract in the Lancet (scroll to the top of the page)

“Image courtesy of [scottchan]/ FreeDigitalPhotos.net

 

Meditation and Art Therapy may reduce stress and anxiety in breast cancer patients.

_MG_1342A study published in the journal Stress and Health has shown that meditation and art therapy may reduce stress and anxiety in breast cancer patients.  Eighteen participants were assigned to an education course or Mindfulness-based Art Therapy (MBAT) consisting of mindful yoga, awareness of breathing, awareness of emotion, and expressive art for 8 weeks.  The patients enrolled in this study had been diagnosed with breast cancer 6 months- 3 years before the study and were not in active treatment.  Participants completed a 90 item symptom checklist at the beginning and end of the study and underwent functional magnetic resonance imaging (fMRI) to examine changes in cerebral blood flow.  Patients in the MBAT group had cerebral blood flow changes in the left insula, amygdala, and hippocampus which deal with emotions and stress and experienced less stress and anxiety. How often do you recommend Mindfulness-based Art Therapy? What other recommendations do you make to your patients to decrease stress?

For more information, please read the article in Stress and Health.

“Image courtesy of [marin]/ FreeDigitalPhotos.net

Genetically different forms of breast cancer discovered

The first comprehensive analysis of breast cancer published in the journal Nature, found that there are four genetically different forms of the disease.  In addition, individual tumors in these forms, may also be driven by their own genetic changes.  How do you believe this information will change the treatment of this disease?

For more information, please see the NY Times.

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