For years, exercise has been recognized as an effective way to prevent stress-induced depression, yet until now the mechanism had not been understood. It was initially believed that trained skeletal muscle produced a substance protective towards the brain. However, researchers at the Karolinska Institutet in Sweden shared their findings using mice models showing something different. Instead of generating a protective substance in the body, the exercised skeletal muscle produces an enzyme that helps to excrete damaging, stress-related substances from the blood. Depression remains to be a widely misunderstood disorder, but this research reinforces the importance of exercise in its treatment and could provide insight into novel therapies. What other non-pharmacological interventions do you recommend to patients who experience stress-induced depression?
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