The study published in JAMA included more than 162,000 depression patients aged 10 to 64 year old, who began taking citalopram, sertraline, or fluoxetine in 1998 to 2010. This was the first study to investigate the risk of suicide based on dose of the antidepressant. The results revealed that in patients aged 10 to 24 years, initiation of a higher than recommended dose doubles the risk of self-harm or suicide, compared to initiation of the recommended dose. This association was not found in patients aged 24 to 64 years. How extensively do you counsel young patients taking antidepressant medications in your practice?
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