ID-100111169The Pharmacist’s Letter recently updated their guidelines for cough and cold medications to use in pregnancy based on a published case-control study. Researchers conducted comparisons with intranasal decongestants overall, including oxymetazoline and xylometazoline, in relation to 30 common specific birth defects. Oxymetazoline was most commonly used amongst the cases in the study. Results showed that there was a statistically significant association with use of intranasal decongestants in the first trimester, specifically oxymetazoline and xylometazoline, and pyloric stenosis. Additionally, a statistically significant association was found linking second-trimester exposure of oxymetazoline to renal collecting system anomalies. How will this information change your cough/cold recommendation for pregnant women? What alternatives can be used for treatment?

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