More than 50% of pregnant women will experience nausea/vomiting symptoms in the early stages of their pregnancy. Though conservative treatment is often attempted, most women will eventually receive drug treatment. Currently metoclopramide is commonly prescribed for treatment of morning sickness in pregnant women and is considered to be safe, but large studies regarding specific malformations and fetal death are lacking. A large cohort study recently published in JAMA studied 1,222,503 pregnancies in Denmark from 1997-2011 and compared metoclopramide exposed and non-exposed women to investigate its safety. Findings showed that there was no significant association between metoclopramide use and risk of congenital malformations overall. How often do you see metoclopramide prescribed for morning sickness? Have pregnant women asked you about its safety?
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