A recent retrospective cohort study published in Annals of Internal Medicine included 107,835 patients from Brigham and Women’s Hospital and Massachusetts General Hospital who were prescribed a statin. Data was collected to evaluate the reasons for statin discontinuation and the prevalence of statin-related events. Researchers found that 17% of patients discontinued statin therapy because of side effects (myalgia or myopathy most commonly), but within a year statin therapy was rechallenged in more than half of these patients and almost 90% continued therapy. How often do your patients report statin-related adverse effects to you? How do you advise them?

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