A double-blinded, placebo-controlled trial recently published in the Journal of the National Cancer Institute evaluated the use of folic acid, vitamin B6, and vitamin B12 in 1,470 women, who were part of a larger study, and the risk of colorectal adenoma.  Researchers concluded that women who took 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 showed no decreased risk of colorectal adenoma compared to placebo.  What counseling points do you generally provide to patients taking these supplements?

For more information, please read the abstract in the Journal of the National Cancer Institute.