A recent open-label, randomized controlled trial published in the BMJ evaluated the long-term effect of hormone replacement therapy (HRT) on heart disease and cardiovascular events in postmenopausal women. Roughly 1,000 women were randomized to receive either HRT or no treatment for about 11 years, with 5 years follow-up after stopping the intervention. Researchers concluded that early initiation of HRT after menopause reduced the risk of cardiovascular events without increasing the risk of other diseases such as breast cancer. What important counseling points would you provide to women on HRT?
For more information, please read the article in BMJ.