The agency is reviewing reports of children who died or developed serious adverse effects after using typical codeine doses for pain relief following tonsillectomy and/or adenoidectomy for obstructive sleep apnea syndrome.  Considered “ultra-rapid metabolizers”, these children were able to convert codeine into life-threatening amounts of morphine.  When prescribing codeine, the lowest dose for the shortest period of time should be used on an as-needed basis.  How will you strive to more actively counsel parents of children regarding warning signs of overdose?

http://www.fda.gov/Drugs/DrugSafety/ucm313631.htm

 

 

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